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KMID : 1059519910350060689
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Journal of the Korean Chemical Society
1991 Volume.35 No. 6 p.689 ~ p.666
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Simultaneous Analysis of Stimulants and Narcotic Analgesics by Capillary Column Gas Chromatography with Nitrogen Phosphorus Detector
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Lho Dong-Seok
Shin Ho-Sang
Kang Bo-Kyung
Paek Hang-Kee
Kim Seung-Ki
Lee Jeong-Ae
Kim Young-Lim
Park Jong-Sei
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Abstract
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A systematic analysis of 18 stimulants and narcotic analgesics containing nitrogen atom (s) in human urine by gas chromatography with nitrogen phosphorus detector (GC-NPD), is described. The urinary extract with diethyl ether at pH 8.5 showed good recoveries of the drugs and less interference peaks on GC chromatogram. Retention data were standardized by the calculation of relative retention times using diphenylamine as the internal standard. The relative standard deviations of retention times were less than 0.1% for the within-run analyses. The response factor (RRF) of a drug relative to the internal standard was calculated. RRF decreased with increasing number of nitrogen atoms. This technique can be adapted to various analytical toxicology problems.
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